The greenovation® Technology

Bryotechnology:

The Bryotechnology uses the small moss Physcomitrella patens as production system for the recombined or genetic production of proteins. The production of proteins in mosses has the advantage that it is simple, reliable and cost efficient. At the same time, after appropriate genetic modifications, the moss is also perfectly suitable for glyco-engineering due to its biological features.

Moss is the only known plant system which shows a high frequency of homologous recombination. This attribute allows for targeted gene insertion as well as for targeted gene knockouts. Homologous recombination is a highly attractive tool for production strain design and is used to knock-out plant-specific glycosylation enzymes. This permits the removal of plant-specific glycosylation patterns and retaining glycosylation patterns that are highly similar to those found in human cells.

The Production Systems:

  • Bryo-Speed™ – The Prototyping-System
    Bryospeed-Logo
    By means of moss protoplasts in the framework of pilot studies within only four to six weeks a customized, qualitatively highly valuable glycoprotein can be produced in low quantities and used for first tests in the laboratory. This guarantees high flexibility for our customers and a fast implementation of their ideas.
  • Bryo-Master™ – The Long Time-Production System
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    Bryotechnology facilitates the production of reliable, long-term stable cell lines. These cells in turn produce the bryotechnologically refined glycoprotein in photo bioreactors according to pharmaceutical standards. This guarantees a very reasonable, robust and reliable large scale production for our customers.