Publications

Treatment of experimental C3 Glomerulopathy by human complement factor H produced in glycosylation-optimized Physcomitrella patens

Karsten Häffner, Juliana Parsons, Lennard L. Bohlender, Sebastian Hoernstein, Holger Niederkrüger, Benjamin Fode, Andreas Busch, Nicola Krieghoff, Jonas Koch, Andreas Schaaf, Thomas Frischmuth, Peter F. Zipfel, Martin Pohl, Ralf Reski, Eva L. Decker, Stefan Michelfelder
Molecular Immunology, Volume 89, September 2017, Page 120

Moss-produced, glycosylation-optimized human factor H for therapeutic application in complement disorders

Michelfelder, S., J. Parsons, L. L. Bohlender, S.N.W. Hoernstein, H. Niederkrüger, A. Busch, N. Krieghoff, J. Koch, B. Fode, A. Schaaf, T. Frischmuth, M. Pohl, P.F. Zipfel, R. Reski, E.L. Decker, K. Häffner
Journal of the American Society of Nephrology 28, 2017

Molecular basis for globotriaosylceramide regulation and enzyme uptake in immortalized aortic endothelial cells from Fabry mice.

Meng XLDay TSMcNeill NAshcraft PFrischmuth TCheng SHLiu ZPShen JSSchiffmann R 
J Inherit Metab Dis. 2016 May

Development of a Novel Host-Cell Protein Assay: Supporting the Physcomitrella patens Expression System

Paulina Dabrowska-Schlepp, Stefan Sommerschuh, Mathias Knappenberger, Holger Niederkrüger, Nicole Gliese and Andreas Schaaf
BioProcess International, Feb. 2016

Biopharmazeutika durch pflanzliche Produktion in geschlossenen Systemen

Holger Niederkrueger, Andreas Schaaf, Christian Koch, Thomas Pultar (2015).
TechnoPharm 5, Nr. 5, 256–265

Mannose receptor-mediated delivery of moss-made α-galactosidase A efficiently corrects enzyme deficiency in Fabry mice

Shen, J.-S., Busch, A., Day, T. S., Meng, X.-L., Yu, C. I., Dabrowska-Schlepp, P., … Schaaf, A. (2015).
Journal of Inherited Metabolic Disease. doi:10.1007/s10545-015-9886-9

Suspension Culture of Plant Cells Under Phototrophic Conditions

Holger Niederkrueger, Paulina Dabrowska-Schlepp, Andreas Schaaf (2014)
Wiley-VCH Verlag, Meyer, H.-P. / Schmidhalter, D. (eds.): Industrial Scale Suspension Culture of Living Cells (978-3-527-33547-3), 8

Moss-based production of asialo-erythropoietin devoid of Lewis A and other plant-typical carbohydrate determinants

Parsons, J., Altmann, F., Arrenberg, C. K., Koprivova, A., Beike, A. K., Stemmer, C., ... Decker, E. L. (2012)
Plant Biotechnology Journal, 10(7), 851–861. doi:10.1111/j.1467-7652.2012.00704.x

Production of biologically active recombinant human factor H in Physcomitrella

Annette Buettner-Mainik, Juliana Parsons, Hanna Jerome, Andrea Hartmann, Stephanie Lamer, Andreas Schaaf, Andreas Schlosser, Peter F. Zipfel, Ralf Reski and Eva L. Decker
Plant Biotechnology Journal (2010), 1–11

Neueste Strategien in der Krebsimmuntherapie

Gilbert Gorr, Ralf Kircheis
Deutsche Zeitschrift für Klinische Forschung (DZKF) 11/12-2007, 33-35

Proteinherstellung: Bryotechnologie – innovatives Tool für rekombinante Proteinproduktion

Gilbert Gorr (2007)
Biospektrum November Ausgabe, 758-760

High-level expression of secreted complex glycosylated recombinant human erythropoietin in the Physcomitrella Delta-fucT Delta-xylT mutant

Weise A, Altmann F, Rodriguez-Franco M, Sjoberg ER, Bäumer W, Launhardt H, Kietzmann M, Gorr G.
Plant Biotechnol J., 2007 May;5(3):389-401

In vivo glyco-engineered antibody with improved lytic potential produced by an innovative non-mammalian expression system

Schuster M., Jost W., Mudde GC., Wiederkum S., Schwager C., Janzek E., Altmann F., Stadlmann J., Stemmer C., Gorr G.(2007)
Biotechnology Journal 2, 700-708

Compensation of endogenous IgG mediated inhibition of antibody-dependent cellular cytotoxicity by glyco-engineering of therapeutic antibodies

Nechansky, A., Schuster, M., Jost, W., Siegl, P., Wiederkum, S., Gorr, G. and Kircheis, R. (2007)
Molecular Immunology 44, 1826-1828

Glycosylation of recombinant proteins in plants

Gorr, G. and Altmann, F. (2006)
Vol. 2: 345-374. In Medicinal Plant Biotechnology (Eds. Kayser, O. and Quax, W.) Wiley-VCH

A fast and flexible PEG-mediated transient expression system in plants for high level expression of secreted recombinant proteins

Baur, A., Kaufmann, F., Rolli, H., Weise, A., Luethje, R., Berg, B., Braun, M., Baeumer, W., Kietzmann, M., Reski, R. and Gorr, G. (2005)
Journal of Biotechnology 119, 332-342

Glycosylation design in transgenic moss for better product efficacy

Gorr, G. and Jost, W. (2005)
Bioprocessing Journal 4, 26-30

Enhanced recovery of a secreted recombinant human growth factor by stabilising additives and by coexpression of human serum albumin in the moss Physcomitrella patens

Baur, A., Reski, R. and Gorr, G. (2005)
Plant Biotechnology Journal 3, 331-340

Glyco-engineering of moss lacking plant-specific sugar residues

Huether, C.M., Lienhart, O., Baur, A., Stemmer, C., Gorr, G., Reski, R. and Decker, E.L. (2005)
Plant Biology, 7, 292-299

Isolation and characterisation of three moss derived beta-tubulin promoters suitable for recombinant expression

Jost, W., Link, S., Horstmann, V., Decker, E.L., Reski, R. and Gorr, G. (2005)
Current Genetics 47, 111-120

Targeted knockouts of Physcomitrella lacking plant-specific immunogenic N-glycans

Koprivova, A., Stemmer, C., Altmann, F., Hoffmann, A., Kopriva, S., Gorr, G., Reski, R., and Decker, E. L. (2004)
Plant Biotechnology Journal 2, 517-523

N-Glycosylation in the moss Physcomitrella patens is organized similarly to higher plants

Koprivova, A., Altmann, F., Gorr, G., Kopriva, S., Reski, R. and Decker, E.L. (2003)
Plant Biology 5, 582-591

Moss – An Innovative Tool for Protein Production

Decker, E.L., Gorr, G. and Reski, R. (2003)
BIOforum Europe 2, 96-97

Tight control of growth and cell differentiation in photoautotrophically growing moss (Physcomitrella patens) bioreactor cultures

Hohe, A., Decker, E.L., Gorr, G., Schween, G. and Reski, R. (2002)
Plant Cell Reports 20, 1135-1140